Lung Niches for the Generation and Maintenance of Tissue-resident Memory T cells

@inproceedings{Turner2014LungNF,
  title={Lung Niches for the Generation and Maintenance of Tissue-resident Memory T cells},
  author={Damian Lanz Turner and Kara L Bickham and J. J. T. Thome and Christine Youngwon Kim and Frank D’Ovidio and Elaine Wherry and Donna L Farber},
  booktitle={Mucosal Immunology},
  year={2014}
}
The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct from populations in lymphoid tissue or circulation. Using a polyclonal mouse model of influenza infection combined with an in vivo antibody labeling approach and confocal imaging, we… CONTINUE READING