Lung Injury After Acute Inhalation Of Perfluoroisobutylene: Exposure Concentration-Response Relationships

@inproceedings{Lehnert1993LungIA,
  title={Lung Injury After Acute Inhalation Of Perfluoroisobutylene: Exposure Concentration-Response Relationships},
  author={Bruce E. Lehnert and D. C. Archuleta and Melissa J. Behr and Douglas M. Stavert},
  year={1993}
}
  • Bruce E. Lehnert, D. C. Archuleta, +1 author Douglas M. Stavert
  • Published 1993
  • Chemistry
  • AbstractPerfluoroisobutylene (PFIB) is a toxic, potentially lethal pneumoedematogenic gas. An investigation was undertaken to examine the kinetic course of the pulmonary injurious response to PFIB when inhaled by adult Fischer 344 rats for 10-min durations at mass concentrations ranging from 50 to 200 mg/m3. No lung gravimetric increases or histopathological changes were observed after exposure to 50 or 83 mg/m3 concentrations of PFIB. At ≥ 90 mg/m3, overt lung injury that was detectable by… CONTINUE READING

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