Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity

@article{Lehmann2009LungEI,
  title={Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity},
  author={Mandy D. Lehmann and Deborah Noack and Malcolm R. Wood and Marta Perego and Ulla G. Knaus},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1369 - 1376}
}
Bacillus anthracis lethal toxin (LT) is a key virulence factor of anthrax and contributes significantly to the in vivo pathology. The enzymatically active component is a Zn(2+)-dependent metalloprotease that cleaves most isoforms of mitogen-activated protein kinase kinases (MKKs). Using ex vivo differentiated human lung epithelium we report that LT destroys lung epithelial barrier function and wound healing responses by immobilizing the actin and microtubule network. Long-term exposure to the… CONTINUE READING

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