Lung Angiogenesis Requires CD4(+) Forkhead Homeobox Protein-3(+) Regulatory T Cells.

@article{DAlessio2015LungAR,
  title={Lung Angiogenesis Requires CD4(+) Forkhead Homeobox Protein-3(+) Regulatory T Cells.},
  author={Franco R. D'Alessio and Qiong Zhong and John Christopher Jenkins and Aigul Moldobaeva and Elizabeth M Wagner},
  journal={American journal of respiratory cell and molecular biology},
  year={2015},
  volume={52 5},
  pages={
          603-10
        }
}
Angiogenesis in ischemic organs is modulated by immune cells. Systemic neovascularization of the ischemic lung requires macrophages, with chemokines playing a central role in new vessel growth. Because regulatory T (Treg) cells modulate tumor-induced neovascularization, we questioned whether this CD4(+) lymphocyte subset impacts blood vessel growth during ischemia. In a model of left lung ischemia, an increase in CD4(+) CD25(+) forkhead homeobox protein-3 (Foxp3)(+) cells was observed 3-5 days… CONTINUE READING
BETA
11
Twitter Mentions

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Effector T Cells and Ischemia-Induced Systemic Angiogenesis in the Lung.

  • American journal of respiratory cell and molecular biology
  • 2016
VIEW 10 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Angiogenesis in the mouse lung.

  • The American journal of pathology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 1 EXCERPT

Chemokines as mediators of neovascularization.

  • Arteriosclerosis, thrombosis, and vascular biology
  • 2008
VIEW 1 EXCERPT