Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation1

@inproceedings{Schtz2015LungAA,
  title={Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation1},
  author={Alexander C. Sch{\"u}tz and K. Roeser and Jana Klitzsch and Franziska Lieder and Fritz Aberger and Wolfgang Gruber and Kristina M. Mueller and Alexander Pupyshev and Richard Moriggl and Karlheinz Friedrich},
  booktitle={Translational oncology},
  year={2015}
}
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in the majority of lung cancer. This study aims at defining connections between STAT3 function and the malignant properties of non-small cell lung carcinoma (NSCLC) cells. To address possible mechanisms by which STAT3 influences invasiveness, the expression of matrix metalloproteinase-1 (MMP-1) was analyzed and correlated with the STAT3 activity status. Studies on both surgical biopsies and on lung cancer… CONTINUE READING

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