Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants.

@article{Kidd2008LuminalRO,
  title={Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants.},
  author={M. Kidd and I. Modlin and B. Gustafsson and I. Drozdov and O. Hauso and R. Pfragner},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 2},
  pages={
          G260-72
        }
}
  • M. Kidd, I. Modlin, +3 authors R. Pfragner
  • Published 2008
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
Mechanisms by which gut luminal content regulates secretion and motility are ill understood. We evaluated whether neuroendocrine enterochromaffin (EC) cells act as luminal sensors for a wide variety of nutrients and defined the secretory mechanisms of this process. Pure (98-99%) FACS-sorted human EC cells and neoplastic EC cells (KRJ-I) were studied. RT-PCR identified transcripts for T2R1 (bitter), OR1G1 (class II olfactory) and trace amine (TAR1) G protein-coupled receptors (GPCRs) and… Expand
185 Citations
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion.
  • A. Chin, B. Svejda, +7 authors M. Kidd
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2012
IL1β‐ and LPS‐induced serotonin secretion is increased in EC cells derived from Crohn’s disease
Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites
Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass
QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells
Regional differences in nutrient‐induced secretion of gut serotonin
Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 107 REFERENCES
Regulation of 5-HT release from enterochromaffin cells
The functional characterization of normal and neoplastic human enterochromaffin cells.
Serotonin and carcinoid tumors.
  • H. Ahlman
  • Medicine
  • Journal of cardiovascular pharmacology
  • 1985
Phenotypic characterization of taste cells of the mouse small intestine.
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.
...
1
2
3
4
5
...