Luminal purinergic regulatory mechanisms of tracheal ciliary beat frequency.

  title={Luminal purinergic regulatory mechanisms of tracheal ciliary beat frequency.},
  author={Lid B. Wong and Donovan B. Yeates},
  journal={American journal of respiratory cell and molecular biology},
  volume={7 4},
To investigate the modulation of tracheal ciliary beat frequency (CBFt) by purine nucleotides and nucleosides acting on luminal receptors, aerosolized ATP, GTP, AMP-PNP, GMP-PNP, adenosine, and guanosine were each administered separately to the tracheal lumen in eucapnically ventilated, barbiturate-anesthetized beagles. Four studies were conducted in each of seven dogs from a cohort of eight dogs. The CBFt responses were measured on the right lateral surface of the mid-trachea using heterodyne… CONTINUE READING
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