Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct.

@article{Sakairi1995LuminalPE,
  title={Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct.},
  author={Yuriko Sakairi and Hilary Jacobson and T D Noland and Matthew D. Breyer},
  journal={The American journal of physiology},
  year={1995},
  volume={269 2 Pt 2},
  pages={F257-65}
}
Prostaglandin E2 (PGE2) is the major renal cyclooxygenase metabolite of arachidonic acid. Urinary excretion of PGE2 is increased by dietary salt restriction, as well in cirrhosis and congestive heart failure. To determine whether urinary PGE2 affects transport along the nephron, the actions of luminal PGE2 were studied in the isolated perfused rabbit cortical collecting duct (CCD). Luminal PGE2 transiently hyperpolarized transepithelial voltage (Vt) in a dose-dependent manner (half-maximal… CONTINUE READING
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