Luminal fluid tonicity regulates airway ciliary beating by altering membrane stretch and intracellular calcium.

@article{Horvath2008LuminalFT,
  title={Luminal fluid tonicity regulates airway ciliary beating by altering membrane stretch and intracellular calcium.},
  author={Gy{\"o}rgy Horvath and Eric Sorscher},
  journal={Cell motility and the cytoskeleton},
  year={2008},
  volume={65 6},
  pages={
          469-75
        }
}
The coordinated, directional beating of airway cilia drives airway mucociliary clearance. Here we explore the hypothesis that airway surface liquid osmolarity is a key regulator of ciliary beating. Cilia in freshly isolated human and murine airways visualized with streaming video-microscopy exhibited a reciprocal dependence on a physiological range of luminal fluid osmolarities, across the entire range of ciliary activity (0-20 beats per sec). Increasing osmolarity slowed or completely… CONTINUE READING