Luminal cells are favored as the cell of origin for prostate cancer.

  title={Luminal cells are favored as the cell of origin for prostate cancer.},
  author={Zhu A. Wang and Roxanne Toivanen and Sarah K. Bergren and Pierre Chambon and Michael M Shen},
  journal={Cell reports},
  volume={8 5},
The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or luminal epithelial cells, or both, represent cells of origin under physiological conditions in vivo. Here, we use a novel lineage-tracing strategy to assess the cell of origin in a diverse range of mouse models, including Nkx3.1(+/-); Pten(+/-), Pten… CONTINUE READING
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