Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules

@inproceedings{Soppina2012LuminalLO,
  title={Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules},
  author={Virupakshi Soppina and Jeffrey F. Herbstman and Georgios Skiniotis and Kristen J Verhey},
  booktitle={PloS one},
  year={2012}
}
The αβ-tubulin subunits of microtubules can undergo a variety of evolutionarily-conserved post-translational modifications (PTMs) that provide functional specialization to subsets of cellular microtubules. Acetylation of α-tubulin residue Lysine-40 (K40) has been correlated with increased microtubule stability, intracellular transport, and ciliary assembly, yet a mechanistic understanding of how acetylation influences these events is lacking. Using the anti-acetylated tubulin antibody 6-11B-1… CONTINUE READING
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MEC17 is an alpha-tubulin acetyltransferase

  • JS Akella, D Wloga, J Kim, NG Starostina, S Lyons-Abbott
  • Nature
  • 2010
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