Luminal DMSO: Effects on Detrusor and Urothelial/Lamina Propria Function

@inproceedings{Smith2014LuminalDE,
  title={Luminal DMSO: Effects on Detrusor and Urothelial/Lamina Propria Function},
  author={Katrina J. Smith and Russ Chess-Williams and Catherine M. McDermott},
  booktitle={BioMed research international},
  year={2014}
}
DMSO is used as a treatment for interstitial cystitis and this study examined the effects of luminal DMSO treatment on bladder function and histology. Porcine bladder was incubated without (controls) or with DMSO (50%) applied to the luminal surface and the release of ATP, acetylcholine, and LDH assessed during incubation and in tissues strips after DMSO incubation. Luminally applied DMSO caused ATP, Ach, and LDH release from the urothelial surface during treatment, with loss of urothelial… CONTINUE READING

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