Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression.

@article{Niewiarowska2011LumicanIA,
  title={Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression.},
  author={Jolanta Niewiarowska and St{\'e}phane Br{\'e}zillon and Izabela Sacewicz-Hofman and Radoslaw Bednarek and F X Maquart and Mariusz Malinowski and Magdalena Wiktorska and Yanusz Wegrowski and Czeslaw S. Cierniewski},
  journal={Thrombosis research},
  year={2011},
  volume={128 5},
  pages={
          452-7
        }
}
INTRODUCTION Previous studies showed that lumican, a small leucine-rich proteoglycan that binds to α2 integrin I domain, is an efficient inhibitor of cell adhesion and migration. In this report, we tested its effect on angiogenesis in vitro and in vivo. MATERIALS AND METHODS Effect of lumican on angiogenesis was evaluated by in vitro capillary tube formation test performed between Fibrin II Gels or in Matrigel™ and in vivo by Matrigel(™) plug assay in BALB/c mice. Changes in matrix… CONTINUE READING
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