• Corpus ID: 36042158

Lumbrokinase in reversing carotid atherosclerotic plaques of patients with ischemic cerebrovascular disease

@inproceedings{Liu2012LumbrokinaseIR,
  title={Lumbrokinase in reversing carotid atherosclerotic plaques of patients with ischemic cerebrovascular disease},
  author={Nengwei. Liu and Jie Wu and Jingfen. Xu and Dongxun. Wu and Wenbin Yang and Yo-Hong Guo and Fu-tang Xie},
  year={2012}
}

• Nengwei. Liu, Jie Wu, +4 authors Fu-tang Xie
• Published 2012
• Medicine

[ABSTRACT] OBJECTIVE: To investigate the effect of lumbrokinase on plasminogen, hemorheology, blood lipid levels and carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease. METHODS: Computer-generated random numbers to divide 60 ischemic cerebrovascular disease patients with carotid artery plaques and abnormal plasminogen levels into treatment group and control group, 30 patients in each group. Treatment group was given lumbrokinase with aspirin, atorvastatin; control group was given aspirin and atorvastatin. Conventional treatments were the same in both groups; treatment period was 6 months. Fibrinogen (FIB), hemorheology, blood lipids and carotid artery color Doppler ultrasound were examined before and after the treatment. RESULTS: After treatment, in the treatment group, the FIB, platelet aggregation, whole blood viscosity and carotid artery intima-media thickness and intimal plaque were lower compared with before treatment, the difference was statistically significant (P <0.05 or P <0.01); improvement level was higher than control group, the difference was statistically significant (P <0.05 or P <0.01). Comparison between before treatment and after treatment in both groups: the total cholesterol, triglyceride, low-density lipoprotein cholesterol were lower and high-density lipoprotein cholesterol were higher, the difference was statistically significant (P <0.01); there was no significant difference in the above parameters (P> 0.05) within the two groups after treatment, but the treatment group had a greater reduction. During treatment, the treatment group had one case with skin itching and two cases with stomach discomfort. There were not any serious adverse reactions in the two groups. CONCLUSION: Lumbrokinase improved microcirculation, activated coagulation, dissolved fibrins, inhibited platelet aggregation and adjusted the role of blood lipids. It also had anti-lipid oxidation, protection of vascular endothelial and other properties. When used in combination with atorvastatin, it reduced atherosclerosis and plaque formation effectively. [Keywords] ischemic cerebrovascular disease; lumbrokinase; hemodynamic; lipid; carotid atherosclerosis [Classification Number] R743.3 [Document code] B [Serial Number] 1673-4777(2009)03-0169-02