Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats.

@article{Sun2013LumbrokinaseAD,
  title={Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats.},
  author={Huili Sun and Na Ge and Mumin Shao and Xiaoyan Cheng and Yue Li and Shunmin Li and Jiangang Shen},
  journal={Diabetes research and clinical practice},
  year={2013},
  volume={100 1},
  pages={85-95}
}
OBJECTIVE The present study was undertaken to investigate the therapeutic effect and underlying mechanisms of lumbrokinase on diabetic nephropathy. METHODS Type I diabetes was induced in male Sprague-Dawley rats via intraperitoneal injection of Streptozotocin (STZ). Lumbrokinase was administered to the diabetic rats at a dose of 600,000 U/kg body weight by gavage. As a positive control, perindopril, an angiotensin-converting enzyme inhibitor (ACEI), was given to diabetic rats at a dose of 4… CONTINUE READING

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