Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

@inproceedings{Xue2016LumbarPR,
  title={Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas},
  author={Song Xue and Shu Xiao-Hong and Sha Sha Lin and Bian Jie and Wang Li-li and Gu Jia-Yao and Shi Shun and Li Pei-nan and Wu Mo-Li and Wang Qian and Chen Xiao-yan and Kong Qing-you and Zhang Zhu Peng and Li Kang Hong and Liu Jia},
  booktitle={Oncotarget},
  year={2016}
}
Trans-resveratrol suppresses glioblastoma growth in vitro, but its effects on intracranial glioblastomas remain untested. Resveratrol crosses the blood-brain barrier, and lumbar puncture (LP) greatly increases its bioavailability in rat brains; therefore, we investigated the effectiveness of LP-administered resveratrol on orthotopic rat glioblastomas. Twenty-four tumor-bearing rats were separated into two groups: Group 1 receiving 100 μl saline containing 0.3% DMSO and Group 2 receiving 100 μl… CONTINUE READING

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