Lumbar catheterization of the subarachnoid space with a 32-gauge polyurethane catheter in the rat.

Abstract

Chronic catheterization of the subarachnoid space of rats is an important tool for intrathecal drug delivery in pharmacologic investigations of pain. We describe a technique using direct lumbar insertion of a small 32-gauge polyurethane (PU) catheter without extensive surgery. Location of the catheter was confirmed with 2% lidocaine injection 1 day later, and methylene blue injection after 7-14 days. This method improved recovery of the rat after catheter implantation and reduced neurologic complications.

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@article{Pogatzki2000LumbarCO, title={Lumbar catheterization of the subarachnoid space with a 32-gauge polyurethane catheter in the rat.}, author={Esther M Pogatzki and Peter K. Zahn and Timothy J. Brennan}, journal={European journal of pain}, year={2000}, volume={4 1}, pages={111-3} }