Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.

@article{Lu1997LumanAN,
  title={Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.},
  author={R Lu and Peirong Yang and Peter O'Hare and Vikas Misra},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 9},
  pages={
          5117-26
        }
}
The human host cell factor (HCF) is expressed in a variety of adult and fetal tissues, and its gene is conserved in animals as diverse as mammals and insects. However, its only known function is to stabilize the herpes simplex virus virion transactivator VP16 in a complex with the cellular POU domain protein Oct-1 and cis-acting regulatory elements in promoters of immediate-early viral genes. To identify a cellular function for HCF, we used the yeast two-hybrid system to identify a cellular… CONTINUE READING
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