Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer


REV.CHIM.(Bucharest)♦68♦No. 8 ♦2017 1944 * email: Phone: +40 740163109 Head and neck cancer represents 3% of malignancies, and it is associated with high mortality due to advanced stage diagnosis. The most frequent histologic type of tumor in this area is the squamous cell carcinoma [1]. Often, in early stages, the symptomatology can either be absent or be very common, and the patients ignore it. Due to late presentation to the ENT specialist, when the tumor is in advanced stages (it has large dimensions, it is invasive affecting the surrounding structures, often with lymph node metastasis and complications – infection, bleeding), the therapeutic resources are limited, and the long-term prognosis is poor. Advanced stage malignancies require extensive surgical procedures with higher risk and greater impact on the patients’ quality of life. Also, complete resection of the tumor with disease-free margins and organ function preservation is more difficult. For these reasons, the medical community is focusing on early diagnostic methods to improve the results of oncologic treatment (surgery, radiotherapy, chemotherapy), survival rate and the quality of life for patients with head and neck cancer. As mentioned before, in early stages a patient with head and neck cancer may present nonspecific symptoms of the organ involved. For example, for nasal carcinoma the most common symptoms are a unilateral nasal obstruction and purulent nasal discharge that can easily be considered rhinosinusitis. Patients with pharyngeal carcinoma can present a persistent sore throat and foreign body sensation, and patients with laryngeal cancer can report hoarseness and breathing difficulties [2]. When discussing head and neck cancer one has to take into account the risk factors: smoking and alcohol abuse are the most important, but occupational exposure to pollutants (asbestos, nickel or wood dust), history of infection with cancer-inducing types of human papilloma virus or Epstein-Barr virus can also play an important part in carcinogenesis [3]. Teething problems can also be a risk factor in the onset of head and neck cancers. Proper dental treatment using composite resins and new dentistry techniques may be seen as protective factors in these cases [4]. Early diagnosis of head and neck carcinoma is mandatory for favorable long-term results. Today, the key for early diagnosis is in vivo examination of the lesion with Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

Cite this paper

@inproceedings{Stefan2017LugolIS, title={Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer}, author={C Stefan and Gabriel Lostun and Alexandra Lostun}, year={2017} }