Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction.

@article{Chen2013LucidoneSH,
  title={Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction.},
  author={Wei-Chun Chen and Sheng-yang Wang and Chien-Chih Chiu and Chin-Kai Tseng and Chun-Kuang Lin and Hsiang-Tsui Wang and Justin Chee Vui Lee},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 3},
  pages={
          1180-91
        }
}
Upon screening of plant-derived natural products against hepatitis C virus (HCV) in the replicon system, we demonstrate that lucidone, a phytocompound, isolated from the fruits of Lindera erythrocarpa Makino, significantly suppressed HCV RNA levels with 50% effective concentrations of 15 ± 0.5 μM and 20 ± 1.1 μM in HCV replicon and JFH-1 infectious assays, respectively. There was no significant cytotoxicity observed at high concentrations, with a 50% cytotoxic concentration of 620 ± 5 μM. In… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Similar Papers

Loading similar papers…