Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.

@article{Kufel2002LsmPA,
  title={Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.},
  author={Joanna Kufel and Christine Allmang and Loredana Verdone and Jean D. Beggs and David Tollervey},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 14},
  pages={5248-56}
}
Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5' and 3' unprocessed species. Aberrant 3'-extended pre-tRNAs were detected, presumably due to stabilization of transcripts that fail to undergo correct transcription termination, and the… CONTINUE READING