Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses

@article{Girkontaite2001LscIR,
  title={Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses},
  author={Irute Girkontaite and Karine Missy and Vadim Sakk and Anke Harenberg and Kerry Tedford and Tobias P{\"o}tzel and Klaus Pfeffer and Klaus-Dieter Fischer},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={855-862}
}
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the Gα13 subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates Gα12 and Gα13. Lsc is expressed primarily in the hematopoietic system and links the activation of Gα12 and Gα13–coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB… CONTINUE READING