Lrp5 functions in bone to regulate bone mass

  title={Lrp5 functions in bone to regulate bone mass},
  author={Yajun Cui and Paul J. Niziolek and Bryan T Macdonald and Cassandra R. Zylstra and Natalia Alenina and Daniel R. Robinson and Zhendong A. Zhong and Susann Matthes and Christina M. Jacobsen and Ronald A. Conlon and Robert Brommage and Qingyun J Liu and Faika Mseeh and David R. Powell and Qi Melissa Yang and Brian P. Zambrowicz and H. J. M. Gerrits and Jan A. Gossen and X I He and Michael Bader and Bart O. Williams and Matthew L Warman and Alexander G. Robling},
  booktitle={Nature Medicine},
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in humans. We found that bone properties in these mice were comparable to bone properties in mice with inherited mutations. We also induced an Lrp5 mutation in cells that form the appendicular skeleton but not in… CONTINUE READING
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