Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

@inproceedings{Riddle2013Lrp5AL,
  title={Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition},
  author={Ryan C Riddle and Cassandra R. Diegel and Julie M. Leslie and Kyle K. Van Koevering and Marie-Claude Faugere and Thomas L. Clemens and Bart O. Williams},
  booktitle={PloS one},
  year={2013}
}
The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial. In these studies, we used Cre-loxP recombination, in which Cre-expression is driven by the human osteocalcin promoter, to determine the individual contributions of Lrp5 and Lrp6 in postnatal bone acquisition and osteoblast function. Mice selectively lacking… CONTINUE READING