Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

@article{Kim2008Lrp4IA,
  title={Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK},
  author={Natalie Kim and Amy L. Stiegler and Thomas O. Cameron and Peter T. Hallock and Andrea M. Gomez and Julie H. Huang and Stevan R Hubbard and Michael L. Dustin and Steven J Burden},
  journal={Cell},
  year={2008},
  volume={135},
  pages={334-342}
}
Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of postsynaptic proteins, including acetylcholine receptors in the muscle membrane and specialized release sites, or active zones in the presynaptic nerve terminal. MuSK, a receptor tyrosine kinase that is expressed in skeletal muscle, and Agrin, a motor neuron-derived ligand that stimulates MuSK phosphorylation, play critical roles in synaptic… CONTINUE READING