Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways.

@article{Zhao2008Lrig3RN,
  title={Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways.},
  author={Hui Ming Zhao and Kosuke Tanegashima and Hyunju Ro and Igor B Dawid},
  journal={Development},
  year={2008},
  volume={135 7},
  pages={1283-93}
}
Leucine-rich repeats and immunoglobulin-like domains 3 (Lrig3) was identified by microarray analysis among genes that show differential expression during gastrulation in Xenopus laevis. Lrig3 was expressed in the neural plate and neural crest (NC) at neurula stages, and in NC derivatives and other dorsal structures during tailbud stages. A prominent consequence of the morpholino-induced inhibition of Lrig3 expression was impaired NC formation, as revealed by the suppression of marker genes… CONTINUE READING
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