Lrig2-Deficient Mice Are Protected against PDGFB-Induced Glioma

  title={Lrig2-Deficient Mice Are Protected against PDGFB-Induced Glioma},
  author={Veronica Rondahl and Camilla Holmlund and Terese Karlsson and Baofeng Wang and Mahmood Faraz and Roger Henriksson and H{\aa}kan Hedman},
  booktitle={PloS one},
BACKGROUND The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, and LRIG3. LRIG1 negatively regulates growth factor signaling, but little is known regarding the functions of LRIG2 and LRIG3. In oligodendroglial brain tumors, high expression of LRIG2 correlates with poor patient survival. Lrig1 and Lrig3 knockout mice are viable, but there have been no reports on Lrig2-deficient mice to date… CONTINUE READING


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