Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection.

@article{Goulding2011LoweringTT,
  title={Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection.},
  author={John C. Goulding and Alexandra Godlee and Seema Vekaria and Markus Hilty and Robert J Snelgrove and Tracy Hussell},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={204 7},
  pages={1086-94}
}
BACKGROUND Previous studies have shown that the interaction of CD200R, a myeloid inhibitory receptor, with its ligand, CD200, is critical in the control of innate immune activation in the lung. METHODS AND RESULTS Using a mouse model of bacterial superinfection following influenza, we show that an absence of CD200R (a negative regulator highly expressed by macrophages and dendritic cells), restricts commensal and exogenous bacterial invasiveness and completely prevents the mortality observed… CONTINUE READING

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