Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen.

@article{Barletta2004LoweringTD,
  title={Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen.},
  author={Janet M. Barletta and Daniel C. Edelman and Niel T. Constantine},
  journal={American journal of clinical pathology},
  year={2004},
  volume={122 1},
  pages={
          20-7
        }
}
Presently, the assay that attains maximal sensitivity and dynamic range of HIV-1 viral copy number (50 copies per milliliter) is nucleic acid amplification of HIV RNA in plasma. Enzyme-linked immunosorbent assay (ELISA) methods for quantification of HIV-1 p24 antigen have been relatively insensitive. In this report, we show data that indicate real-time immuno-polymerase chain reaction (IPCR), a combination of the ELISA and PCR techniques, is more sensitive for HIV-1 p24 antigen detection than… CONTINUE READING

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