Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.

  title={Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.},
  author={Alaa Othman and Roberto Bianchi and Irina Alecu and Yu Qing Wei and Carla Porretta-Serapiglia and Raffaella Lombardi and Alessia Chiorazzi and Cristina Meregalli and Norberto Oggioni and Guido Cavaletti and Giuseppe Lauria and Arnold von Eckardstein and Thorsten Hornemann},
  volume={64 3},
1-Deoxysphingolipids (1-deoxySLs) are atypical neurotoxic sphingolipids that are formed by the serine-palmitoyltransferase (SPT). Pathologically elevated 1-deoxySL concentrations cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), an axonal neuropathy associated with several missense mutations in SPT. Oral L-serine supplementation suppressed the formation of 1-deoxySLs in patients with HSAN1 and preserved nerve function in an HSAN1 mouse model. Because 1-deoxySLs also are elevated… CONTINUE READING
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