Lowering effect of phenolic glycosides on the rise in postprandial glucose in mice.

@article{Takii1997LoweringEO,
  title={Lowering effect of phenolic glycosides on the rise in postprandial glucose in mice.},
  author={Hiroshi Takii and K. Matsumoto and Takashi Kometani and Shigetaka Okada and Tohru Fushiki},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1997},
  volume={61 9},
  pages={
          1531-5
        }
}
Glycosides were screened for their lowering effect on the postprandial blood glucose rise in vivo. The effect of phlorizin and other phenolic glycosides on the postprandial blood glucose response to glucose ingestion was evaluated in Std ddY mice. When phlorizin was simultaneously added, the peak blood glucose level was significantly decreased by 51% (p < 0.01) compared to vehicles following glucose ingestion by mice, while the blood insulin responses were generally similar. Screening… Expand
Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats
TLDR
Beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats and this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity. Expand
Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice.
TLDR
This study shows that Grz has an antidiabetic effect in noninsulin-dependent diabetes model mice and significantly lowered blood insulin level. Expand
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.
Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandialExpand
Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats.
TLDR
Investigation of absorption and metabolism of quercetin and isoquercitrin in rats after in situ perfusion of jejunum plus ileum found efficiency of the absorption seemed to be linked to the intestinal conjugation process and to the luminal secretion of metabolites. Expand
THE EFFECTS OF AEROBIC TRAINING AND ARBUTIN ON GLP1 AND GLP1R IN DIABETES RATS
TLDR
It is demonstrated that a AT course along with the use of arbutin increase the GLP-1 and GLP1R levels in rats with alloxan-induced hyperglycaemia, also AT showed more effectiveness. Expand
Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice.
TLDR
The diet containing phloridzin reduces the blood glucose levels and the hepatic gene expressions associated with some metabolic functions in mice and suppressed the citrate cycle, gluconeogenesis, fatty acid metabolism, and valine, leucine, and isoleucine degradation in mice. Expand
Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study.
TLDR
The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health-promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes. Expand
From molecule to men: Inhibition of intestinal glucose absorption by polyphenols and plant extracts for reducing the glycemic response
In the present work it was investigated whether selected plant extracts and individual polyphenolic compounds are able to inhibit intestinal glucose transporters (SGLT1, GLUT2) and can in turn reduceExpand
Influence of Lactase on the In Vitro and In Vivo Antiglycaemic Effects of Onion Flavonoids
TLDR
Inhibition of glycaemic response by onion: a comparison between lactose-tolerant and intolerant adults and effect of dietary flavonoids on glucose uptake in the presence of lactase. Expand
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
TLDR
Optimized compound 14c showed an improved profile satisfying both higher activity and lower permeability of its aglycone compared with initial leads 1 and 2 and the superior efficacy of 14c in various carbohydrate tolerance tests in diabetic rat models was confirmed compared with acarbose, an α-glucosidase inhibitor widely used in the clinic. Expand
...
1
2
3
4
...