Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

@article{Watanabe2011LoweringBA,
  title={Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.},
  author={Mitsuhiro Watanabe and Yasushi Horai and Sander M. Houten and Kohkichi Morimoto and Taichi Sugizaki and Eri Arita and Chikage Mataki and Hiroyuki Sato and Yusuke Tanigawara and Kristina Schoonjans and Hiroshi Itoh and Johan Auwerx},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 30},
  pages={26913-20}
}
We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet. Administration of GW4064 accentuated body weight gain and glucose intolerance induced by the high fat diet and led to a pronounced worsening of the changes in liver and adipose tissue. Mechanistically, treatment with GW4064 decreased bile acid (BA) biosynthesis, BA pool size, and energy expenditure, whereas… CONTINUE READING
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