Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

@inproceedings{Netzer2010LoweringL,
  title={Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model},
  author={William Joseph Netzer and Craig M. Powell and Yi Nong and Jacqueline J Blundell and Lili Wong and Karen E Duff and Marc Flajolet and Paul Greengard},
  booktitle={PloS one},
  year={2010}
}
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might… CONTINUE READING

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