Lowered cerebral glucose utilization in amyotrophic lateral sclerosis.

  title={Lowered cerebral glucose utilization in amyotrophic lateral sclerosis.},
  author={Marinos C. Dalakas and Jun Hatazawa and Rodney A. Brooks and Giovanni Di Chiro},
  journal={Annals of neurology},
  volume={22 5},
Regional cerebral metabolic rates for glucose (rCMRGlc) were analyzed in 19 studies of 12 patients with amyotrophic lateral sclerosis (ALS) by positron emission tomography (PET) with [18F]2-fluoro-2-deoxy-D-glucose. In the 8 ALS patients with upper motor neuron signs, the mean cortical rCMRGlc was significantly lower than in 11 age-matched control subjects (p less than 0.01). The degree of hypometabolism correlated with the duration of the clinical signs and extended throughout the cortex and… CONTINUE READING
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