Lower versus higher hemoglobin threshold for transfusion in septic shock.

@article{Holst2014LowerVH,
  title={Lower versus higher hemoglobin threshold for transfusion in septic shock.},
  author={Lars Broks{\o} Holst and Nicolai Haase and J{\o}rn Wetterslev and Jan Wernerman and Anne Berit Guttormsen and Sari Karlsson and P{\"a}r Ingemar Johansson and Anders {\AA}neman and Marianne Lauridsen Vang and Robert Winding and Lars Nebrich and Helle Lykkeskov Nibro and Bodil Steen Rasmussen and Johnny Rene Meilstrup Lauridsen and Jane Stab Nielsen and Anders Oldner and Ville Pettil{\"a} and Maria Cronhjort and Lasse H{\o}gh Andersen and Ulf G{\o}ttrup Pedersen and Nanna Reiter and J{\o}rgen Wiis and Jonathan O White and Lene Russell and Klaus J Thornberg and Peter Buhl Hjortrup and Rasmus G. M{\"u}ller and Morten Hylander M{\o}ller and Morten Steensen and Inga Tj{\"a}der and Kristina Kilsand and Suzanne Odeberg-Wernerman and Brit {\AA}. Sj{\o}b{\o} and Helle Bundgaard and Maria A Thy{\o} and D Lodahl and Rikke M{\ae}rkedahl and Carsten Albeck and Dorte G Illum and Mary Murphy Kruse and Per Winkel and Anders Perner},
  journal={The New England journal of medicine},
  year={2014},
  volume={371 15},
  pages={
          1381-91
        }
}
BACKGROUND Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established. METHODS In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin level was 7 g per deciliter or less (lower… 

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To the Editor: In their article on red-cell transfusion, Murphy et al. (March 12 issue)1 report substantial nonadherence to treatment in both study groups — one of which had a restrictive threshold
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