• DOI:10.1056/NEJMoa1406617
Corpus ID: 16280618

Lower versus higher hemoglobin threshold for transfusion in septic shock.

@article{Holst2014LowerVH,
  title={Lower versus higher hemoglobin threshold for transfusion in septic shock.},
  author={L. Holst and N. Haase and J. Wetterslev and J. Wernerman and A. Guttormsen and S. Karlsson and P. Johansson and A. Aneman and M. Vang and R. Winding and Lars Nebrich and H. Nibro and B. Rasmussen and J. Lauridsen and J. S. Nielsen and A. Oldner and V. Pettil{\"a} and M. Cronhjort and L. H. Andersen and U. G. Pedersen and Nanna Reiter and J. Wiis and Jonathan O White and L. Russell and K. Thornberg and P. B. Hjortrup and R. M{\"u}ller and M. M{\o}ller and M. Steensen and I. Tj{\"a}der and Kristina Kilsand and S. Odeberg-Wernerman and Brit {\AA}. Sj{\o}b{\o} and H. Bundgaard and Maria A Thy{\o} and D. Lodahl and Rikke M{\ae}rkedahl and Carsten Albeck and Dorte G Illum and M. Kruse and P. Winkel and A. Perner},
  journal={The New England journal of medicine},
  year={2014},
  volume={371 15},
  pages={
          1381-91
        }
}

• L. Holst, N. Haase, +39 authors A. Perner
• Published 2014
• Medicine
• The New England journal of medicine

BACKGROUND Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established. METHODS In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin level was 7 g per deciliter or less (lower… Expand