Lower urinary tract symptoms (LUTS) and bladder afferent activity.

  title={Lower urinary tract symptoms (LUTS) and bladder afferent activity.},
  author={Naoki Yoshimura},
  journal={Neurourology and urodynamics},
  volume={26 6 Suppl},
AIMS Dysregulation of bladder afferent activity and detrusor smooth muscle behavior leads to a constellation of lower urinary tract symptoms (LUTS), which includes overactive bladder (OAB). Current treatments for LUTS are poorly tolerated and may be associated with substantial adverse effects. METHODS Major advances in the understanding of bladder neuroanatomy and the role of bladder afferent pathways in symptom generation suggest a range of targets for new therapeutic agents. RESULTS A… CONTINUE READING