Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress.

@article{Hanson2015LowerSI,
  title={Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress.},
  author={Jamie L. Hanson and Annchen Knodt and Bartholomew D. Brigidi and Ahmad R. Hariri},
  journal={Development and psychopathology},
  year={2015},
  volume={27 4 Pt 2},
  pages={1611-9}
}
The experience of child maltreatment is a significant risk factor for the development of later internalizing disorders such as depression and anxiety. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for such "stress sensitization," little is known about the mechanisms mediating such relationships, particularly within the brain. Here we report that the experience of child maltreatment independent of recent life… CONTINUE READING
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