Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates
@article{Czoty2010LowerRS, title={Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates}, author={Paul W. Czoty and Jennifer L. Martelle and F. Ivy Carroll and Michael A. Nader}, journal={Pharmacology Biochemistry and Behavior}, year={2010}, volume={96}, pages={274-278} }
13 Citations
2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter
- Biology, ChemistryThe Journal of Pharmacology and Experimental Therapeutics
- 2014
The locomotor-stimulant effects of RTI-371 were comparable in wild-type and knockout cannabinoid CB1 receptor (CB1R) mice, indicating that previously reported CB1 allosteric effects do not decrease cocaine-like effects ofRTi-371.
2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations
- Biology, ChemistryThe Journal of Pharmacology and Experimental Therapeutics
- 2016
Behavioral, biochemical, and computational results show that aryltropane analogs can bind to the DAT and stabilize outward-facing DAT conformations like cocaine, yet produce effects that differ from those of cocaine.
Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys.
- Biology, PsychologyExperimental and clinical psychopharmacology
- 2012
Chronic treatment with RTI-336 has a mild but significant stimulant effect, as evidenced by the significant increase in activity during the evening period which may cause minor disruptions in sleep measures.
Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents
- BiologyThe AAPS Journal
- 2011
The ability of SN79 to significantly attenuate the acute and subchronic effects of cocaine provides a promising compound lead to the development of an effective pharmacotherapy against cocaine.
The Atypical Stimulant and Nootropic Modafinil Interacts with the Dopamine Transporter in a Different Manner than Classical Cocaine-Like Inhibitors
- Biology, PsychologyPloS one
- 2011
Modafinil displayed affinity ratios similar to those of benztropine, GBR12909 and bupropion, but far different than those of cocaine, β-CFT or methylphenidate, and it was demonstrated that the conformational effects of a given DAT inhibitor influence its phenomenological effects.
Medication Development for the Treatment of Cocaine Addiction – Progress at Preclinical and Clinical Levels
- Psychology, Biology
- 2012
This review article will focus on those medication strategies that are well-studied in experimental animals and are currently under clinical trials for the treatment of addiction or for other diseases, including DAT-based agonist therapy, DA receptor-based antagonist therapy, glutamate- based therapy, GABA-based therapy and endocannabinoid-based Therapy.
Agonist replacement therapy for cocaine dependence: a translational review.
- Biology, PsychologyFuture medicinal chemistry
- 2012
The translational review suggests that agonist-replacement therapy, especially monoamine releasers, may be effective for managing cocaine dependence.
Predicting abuse potential of stimulants and other dopaminergic drugs: Overview and recommendations
- Psychology, BiologyNeuropharmacology
- 2014
Cocaine Interaction with Dopamine Transporter in the Prefrontal Cortex and Beyond
- Psychology, Biology
- 2018
Although the relevant research investment in understanding the mechanism of action of cocaine and its role in altering brain circuits and behaviour has not been found yet, cocaine use, dependence, abuse and addiction are still a relevant health, social, and economical problem.
Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine
- Psychology, BiologyNeuropharmacology
- 2019
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