Lower rather than higher levels of B-type natriuretic peptides (NT-pro-BNP and BNP) predict short-term mortality in end-stage heart failure patients treated with nesiritide.

@article{Miller2005LowerRT,
  title={Lower rather than higher levels of B-type natriuretic peptides (NT-pro-BNP and BNP) predict short-term mortality in end-stage heart failure patients treated with nesiritide.},
  author={Wayne Miller and John C Jr. Burnett and Karen A. Hartman and Michael Henle and Mary F. Burritt and Allan S. Jaffe},
  journal={The American journal of cardiology},
  year={2005},
  volume={96 6},
  pages={
          837-41
        }
}
Elevated plasma natriuretic peptides in heart failure (HF) usually indicate a poor outcome and low levels a compensated state. In advanced chronic HF, however, low levels may reflect an impaired neurohormonal response. To assess this hypothesis, this study analyzed whether N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) and B-type natriuretic peptide (BNP) levels were related to mortality in 40 patients treated for decompensated chronic HF. Cardiovascular mortality during follow-up (10… CONTINUE READING

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