Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects.

@article{Relling1991LowerPO,
  title={Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects.},
  author={Mary V. Relling and J. B. Cherrie and Michael J. Schell and William P. Petros and William Meyer and William E. Evans},
  journal={Clinical pharmacology and therapeutics},
  year={1991},
  volume={50 3},
  pages={308-13}
}
Our objective was to determine whether there are differences in debrisoquin hydroxylase (P450IID6) activity between American black subjects and white subjects. Phenotype was assigned in a group of 586 unrelated white and black children with use of dextromethorphan as the substrate probe. Restriction fragment length polymorphism analysis of genomic deoxyribonucleic acid (DNA) was performed in a subset of subjects by use of a full length complementary DNA for P450IID6. Thirty-seven of 480 (7.7… CONTINUE READING

From This Paper

Topics from this paper.
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…