Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study.

@article{Ble2006LowerPV,
  title={Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study.},
  author={Alessandro Ble and Antonio Cherubini and Stefano Volpato and Benedetta Bartali and Jeremy D. Walston and Beverly Gwen Windham and Stefania Bandinelli and Fulvio Lauretani and Jack Guralnik and Luigi Ferrucci},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2006},
  volume={61 3},
  pages={278-83}
}
BACKGROUND The primary biologic mechanism that causes frailty in older persons has never been adequately explained. According to recent views, oxidative stress may be the driving force of this condition. We tested the hypothesis that, independent of confounders, low plasma levels of vitamin E (alpha-tocopherol), the main fat-soluble human antioxidant, are associated with the frailty syndrome in older persons free from dementia and disability. METHODS The study sample included 827 older (> or… CONTINUE READING