Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role.

@article{Fiore2009LowerLO,
  title={Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role.},
  author={Emilio Fiore and Teresa Rago and Maria Annateresa Provenzale and Maria Scutari and Clara Ugolini and Fulvio Basolo and Giancarlo Di Coscio and P. Berti and Lucia Grasso and Rossella Elisei and Aldo Pinchera and Paolo Vitti},
  journal={Endocrine-related cancer},
  year={2009},
  volume={16 4},
  pages={1251-60}
}
Higher TSH values, even within normal ranges, have been associated with a greater risk of thyroid malignancy. The relationship between TSH and papillary thyroid cancer (PTC) has been analyzed in 10 178 patients submitted to fine needle aspiration of thyroid nodules with a cytology of PTC (n=497) or benign thyroid nodular disease (BTND, n=9681). In 942 patients, submitted to surgery (521 from BTND and 421 from PTC), the histological diagnosis confirmed an elevated specificity (99.6%) and… CONTINUE READING