Lower expression of PD-1 and PD-L1 in peripheral blood from patients with chronic ITP.

@article{Zhong2016LowerEO,
  title={Lower expression of PD-1 and PD-L1 in peripheral blood from patients with chronic ITP.},
  author={Jun Zhong and Shaohua Chen and Ling Xu and Jing Wei Lai and Ziwei Liao and Tao Zhang and Zhi Yu and Yuhong Lu and Lijian Yang and Xiu-li Wu and Bo Li and Yangqiu Li},
  journal={Hematology},
  year={2016},
  volume={21 9},
  pages={552-7}
}
BACKGROUND T-cell dysregulation is a major event involved in immune thrombocytopenic purpura (ITP). Increasing data have indicated that abnormal expression of T-cell immunosuppressive receptors, such as programmed death (PD) 1 and cytotoxic T lymphocyte antigen-4 (CTLA-4), may be related to autoimmune disease pathogenesis. METHODS We analyzed the expression levels of PD-1, its ligand PD-L1, and CTLA-4 in peripheral blood mononuclear cells from 18 patients with chronic ITP by real-time… CONTINUE READING