Lower esophageal sphincter responses to enteric hormones in two patients with Zollinger-Ellison syndrome

@article{BSWCWu1975LowerES,
  title={Lower esophageal sphincter responses to enteric hormones in two patients with Zollinger-Ellison syndrome},
  author={MB BSW.C.Wu and Walter J. Hogan and George E. Whalen and Samuel E. Hoke and Vay Liang W. Go and R. K. Kalkhoff},
  journal={The American Journal of Digestive Diseases},
  year={1975},
  volume={20},
  pages={716-720}
}
The effect of exogenous glucagon and secretin on resting lower esophageal sphincter (LES) tone during endogenous hypergastrinemia was studied in 2 patients with proven Zollinger-Ellison Syndrome (ZES). Intravenous glucagon and in one patient secretin, in dosages which decrease LES pressure in normals only during LES stimulation by exogenous gastrin, caused a decrease in resting LES pressure in the ZES patients. This drop in LES tone occurred both during concomitant serum gastrin rise caused by… CONTINUE READING

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