Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice.

@article{Sivarao2001LowerES,
  title={Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice.},
  author={Digavalli V. Sivarao and Hiroshi Mashimo and H S Thatte and Raj K. Goyal},
  journal={Gastroenterology},
  year={2001},
  volume={121 1},
  pages={34-42}
}
BACKGROUND AND AIMS It has been proposed that nitrergic nerves mediate lower esophageal sphincter (LES) relaxation with intramuscular interstitial cells of Cajal (ICC-IM) as an intermediary. Dysfunction of the nitrergic pathway has been shown to cause LES hypertension and impaired relaxation in achalasia. We determined whether mice with neuronal nitric oxide synthase gene disruption (nNOS(-/-)) and W/W(v) mice lacking ICC-IM have achalasia-like LES dysfunction. METHODS Intraluminal manometry… CONTINUE READING
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