Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study.

@article{Lai2010LowerDP,
  title={Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study.},
  author={Adriana Lai and Lorenza Sassi and Emanuele Compri and Franca Marino and Paolo Sivelli and Eliana Piantanida and Maria Laura Piera Tanda and Luigi Bartalena},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 3},
  pages={1333-7}
}
CONTEXT Radioiodine (RAI) therapy may cause progression of mild or absent Graves' orbitopathy (GO), preventable by oral prednisone. Optimal doses of prednisone are undefined. OBJECTIVE The aim of this study was to compare the effectiveness of reported doses [starting dose, >0.3 mg/kg body weight (bw)], and lower (<0.3 mg/kg bw)] doses of prednisone. DESIGN AND SETTING We conducted a retrospective matched cohort study at a University Center. PATIENTS Of 111 RAI-treated Graves' patients… CONTINUE READING