Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine.

@article{Dean2014LowerCS,
  title={Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine.},
  author={Brian Dean and Nahed Tawadros and Myoung Suk Seo and Won Je Jeon and Ian Everall and Elizabeth Scarr and Andrew S. Gibbons},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 6},
  pages={895-906}
}
We have attempted to replicate studies showing higher levels of serotonin 2A receptors (HTR2A) in the cortex of people with mood disorders and to determine the effects of treating rats with antidepressant drugs on levels of that receptor. In situ [3H]ketanserin binding and autoradiography was used to measure levels of HTR2A in Brodmann's area (BA) 46 and 24 from people with major depressive disorders (MDD, n = 16), bipolar disorders (BD, n = 14) and healthy controls (n = 14) as well as the… CONTINUE READING
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