Lower core body temperature and attenuated nicotine-induced hypothermic response in mice lacking the beta4 neuronal nicotinic acetylcholine receptor subunit.

@article{Sack2005LowerCB,
  title={Lower core body temperature and attenuated nicotine-induced hypothermic response in mice lacking the beta4 neuronal nicotinic acetylcholine receptor subunit.},
  author={Ram A Sack and Alona Gochberg-Sarver and Uri Rozovsky and Merav Kedmi and Serena Rosner and Avi Orr-Urtreger},
  journal={Brain research bulletin},
  year={2005},
  volume={66 1},
  pages={30-6}
}
Diverse physiological and pathological effects of nicotine, including the alteration of body temperature, are presumably mediated by neuronal nicotinic acetylcholine receptors (nAChR). Previous studies have suggested the involvement of distinct nAChR subunits in nicotine-induced thermoregulation. We studied genetically manipulated knockout mice lacking the alpha7, alpha5 or beta4 subunit genes, in order to assess the effects of subunit deficiency on temperature regulation. Using a telemetry… CONTINUE READING
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Poten - tial regulation of nicotine and ethanol actions by alpha 4 - containing nicotinic receptors

  • S. E. McCallum T. Tritto, S. A. Waddle, S. R. Hutton, R. Paylor, A. C. Collins, M. J. Marks
  • Alcohol
  • 2001

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