Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional Longevity without compromise to muscle mass and function

@inproceedings{Perice2016LowerCI,
  title={Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional Longevity without compromise to muscle mass and function},
  author={Leland Perice and Nir Barzilai and Joe Verghese and Erica F. Weiss and Roee Holtzer and Pinchas Cohen and Sofiya Milman},
  booktitle={Aging},
  year={2016}
}
Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test… CONTINUE READING
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