Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism

@article{Maes1996LowerSL,
  title={Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism},
  author={Michael Maes and Annick Wauters and Robert Verkerk and P. Demedts and Hugo Neels and Ann van Gastel and Paul Cosyns and Simon Scharp{\'e} and Roger Desnyder},
  journal={Neuropsychopharmacology},
  year={1996},
  volume={15},
  pages={243-251}
}
Recently, it has been reported that major and melancholic depression are accompanied by a lower availability of total L-tryptophan (L-TRP) to the brain and by significant changes in electrophoretically separated protein fractions, such as albumin and α2-globulin. The aim of this study was to examine the relationships between serum L-TRP availability and total serum protein, albumin, and α2-globulin in 42 depressed and 24 normal subjects. In depressed and normal subjects, alone and together… CONTINUE READING

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